| abstract |
Provided are anti-human 4-1BB antibodies and fragments thereof with one or more structural features not found in a reference anti-human 4-1BB antibody, wherein said features may improve certain features of the antibody with respect to the reference antibody. Various in vitro and in vivo methods and reagents related to the anti-human 4-1BB antibodies described herein are also provided. Methods include, for example, inducing T cell proliferation, inducing T cell secretion of IFNγ, as well as detecting, preventing, and/or therapeutically treating cancer using an anti-human 4-1BB antibody or fragment thereof. |