abstract |
Compositions comprising oxygenated cholesterol sulfates (ocs) are provided. the ocs is, for example, 5-cholesten-3,25-diol, 3-sulfate (25hc 3s) or 5-cholestene, 3,2-diol, disulfate (25hcds). The compositions may be used to prevent and / or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure due to acetaminophen), high cholesterol / high lipids, and various inflammatory diseases and conditions. |