| abstract |
methods and compositions for treating conditions associated with an abnormal inflammatory response. this disclosure has chemical entities (for example, a compound that exhibits activity as a mitochondrial uncoupling agent or a pharmaceutically acceptable salt and/or hydrate and/or cocrystal thereof; for example, a compound such as niclosamide or a pharmaceutically acceptable salt and/or hydrate and/or cocrystal thereof, for example a compound such as a niclosa-amide analogue, or a pharmaceutically acceptable salt and/or hydrate and/or cocrystal thereof) which are useful, for example, to treating one or more symptoms of a condition characterized by an abnormal inflammatory response (eg, inflammatory bowel disease) in an individual (eg, a human). this description likewise features compositions, as well as other methods of use and preparation thereof. |