| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_968c7a35f4d590e7dc4262f1892bf2c5 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6939
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1641
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6951
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6907
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1682 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate |
2016-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c4cd34a8176cc1a5247d6e828fb5741 |
| publicationDate |
2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-112017025631-A2 |
| titleOfInvention |
aqueous ophthalmic compositions, method of inducing or enhancing tear formation, method of forming cyclosporin agglomerates a and use of cyclosporin a |
| abstract |
The present invention relates to methods of forming cyclosporin / cyclodextrin complex nanoparticles and microparticles and administering the nano- and microsuspension formed to an eye of a human or animal in the form of aqueous eye drops suitable for obtaining or enhancing the formation of tear and for the treatment of eye diseases and surrounding areas. The aqueous eye drops composition contains cyclosporin and a mixture of α-cyclodextrin and β-cyclodextrin, as well as one or more stabilizing polymers. α-Cyclodextrin solubilizes cyclosporine, while α-Cyclodextrin promotes the formation of cyclosporine / cyclodextrin complex aggregates. the polymers stabilize aqueous nano- and micro-suspension. |
| priorityDate |
2015-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |