| abstract |
The present invention relates to a derivative of an fgf21 protein having a cysteine residue at a position corresponding to position 167, 169, 170, 171, 172, 173, 174, 175 and in particular position 180 or position 181. of mature human gff21 and derivatives thereof having a side chain linked to this cysteine. The fgf21 derivatives of the invention have high potency for fgf receptors. The invention also relates to pharmaceutical compositions comprising such fgf21 derivatives and pharmaceutically acceptable excipients, as well as the medical use of fgf21 derivatives. |