| abstract |
DIOXOLAN ANALOGS OF URIDINE FOR THE TREATMENT OF CANCER. The invention provides compounds of formula (I), wherein: R1 is OR11 or NR5R5'; R2 is H or F; R5 is H, C1-C6 alkyl, OH, C(=O)R6, O(C=O)R6 or O(C=O)OR6; R5? is H or C1-C6 alkyl; R6 is C1-C6 alkyl or C3-C7 cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl, wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are for use in the treatment of cancer and related aspects. |