| abstract |
methods, kits and apparatus to enlarge a cell population. the present invention relates to an in vitro method of expanding a population of cells such as lymphocytes, comprising contacting a sample comprising a population of cells with a multimerization reagent. the multimerization reagent has reversibly immobilized (attached thereto) a first agent that provides a primary activation signal to the cells and optionally, a second agent that provides a costimulatory signal. the invention likewise provides multimerization reagents, kits, arrangements and an apparatus for expanding cells. |