| abstract |
The invention relates to the field of pharmacology. in particular, it relates to novel apelin analogs, and their therapeutic uses. A cyclic analog of apine of formula x1-x2-x3-x4-x5-x6-x7-x8-x9-x10-x11-x12-x13-x14, comprising a lanthionine bridge having the ala-s- ala or a methylthionine bridge having the abu-s-ala or ala-s-abu structure and wherein said (methyl) lanthionine bridge is size i, i + 3; i, i + 4, i, i + 5 or i, i + 6. |