| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_364361dcadbe698011b0554cccff370b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D455-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C221-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C223-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 |
| filingDate |
2014-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e1450e66ba414517bc8418a21cb1ea5 |
| publicationDate |
2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-112016012747-B1 |
| titleOfInvention |
PROCESS FOR PREPARING A RACEMIC MIXTURE OF (RR,SS)-D6-TETRABENAZINE |
| abstract |
METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS The present invention relates to novel methods of manufacturing vesicular benzoquinoline inhibitors of monoamine transporter 2 (VMAT2) and its intermediates. Novel methods of making benzoquinoline compounds of Formula (I), including tetrabenazine analogues and deuterated tetrabenazine such as d6-tetrabenazine are described herein. Tetrabenazine is a vesicular inhibitor of monoamine transporter 2 (VMAT2) and is commonly prescribed for the treatment of Huntington's disease. D6-tetrabenazine is a deuterated analogue of tetrabenazine that has improved pharmacokinetic properties compared to the non-deuterated drug and is currently in clinical development. (I) |
| priorityDate |
2013-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |