| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 |
| filingDate |
2014-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_176d75ba2b53b9a59440f8df30e57933
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f020c7faffb39965ee0188c84809fe21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9ee12e497a61a5824dee37d35ebe4c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7e1912a6ab2e3ab0f69c15b0f8ed655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbd09cac7126493d7988fce1cbef1262 |
| publicationDate |
2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-112015031277-A2 |
| titleOfInvention |
INSULIN RECEPTOR MODULATORS FROM STABILIZED POLYPEPTIDES, INSULIN ANALOGS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID POLYPEPTIDES AND METHODS OF PREPARATION AND USES THEREOF |
| abstract |
INSULIN RECEPTOR MODULATORS FROM STABILIZED POLYPEPTIDES, INSULIN ANALOGS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID POLYPEPTIDES AND PREPARATION METHODS AND USES THEREOF. Provided herein are stabilized (ALFA)-CT polypeptides comprising an alpha-helical segment and wherein the polypeptide is of Formula (I-1) or Formula (I-2): Rf-[XAA]s-XA1-XA2-XA3 -XA4-XA5-XA6-XA7-XA8-XA9-XA10-XA11-XA12-XA13-XA14-[XAA]t-Re(I-1)Rf-[XAA]s-XC1-XC2-XC3-XC4-XC5 -XC6-XC7-XC8-XC9-XC10-XC11-XC12-XC13-XC14-XC15-XC16-XC17-XC18-XC19-XC20-[XAA]t-Re(I-2) in which the Alpha-CT polypeptide is binds to the insulin receptor and wherein the Alpha-CT polypeptide includes at least one hairpin (i.e., two cross-linked amino acids) and/or at least one seam (i.e., three cross-linked amino acids). Further provided are insulin analogues which include stapled or stitched Alpha-CT polypeptides, pharmaceutical compositions thereof, methods of use, for example, methods of treating a diabetic condition or complications thereof. |
| priorityDate |
2013-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |