| abstract |
COMPOUNDS OF SUBSTITUTED 2-AZABBICYCLES, PHARMACEUTICAL COMPOSITION INCLUDING SUCH COMPOUNDS AND USES THEREOF. The present invention is directed to compounds of formula I: I wherein X is N or CR1; Y is N or CR2; R1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl or pyrazolyl; R2 is H, alkyl, alkoxy or halo; Z is NH or O; R3 is H, alkyl, alkoxy, halo or triazolyl; R4 is H or alkyl; or R3 and R4, together with the atoms to which they are attached, form a 6-membered aryl ring or a 6-membered heteroaryl ring; R5 is pyridyl, pyrazinyl or pyrimidinyl, characterized in that the pyridyl, pyrazinyl or pyrimidinoyl is optionally substituted by halo or alkyl; and n is 1 or 2. Methods for producing compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention. |