| abstract |
Summary prodrugs of multifunctional nitroxide derivatives and their uses The invention provides prodrug compounds comprising a nitric oxide donor and a degradative catalyst for reactive oxygen species (ros), in particular 1-pyrrolidinyloxy, piperidinyloxy-1 , and 1-azepanyloxy derivatives, and their pharmaceutical compositions. These compounds and pharmaceutical compositions are useful in the prevention, treatment or management of diseases, disorders or conditions associated with oxidative stress or endothelial dysfunction. 1/1 |