| abstract |
Summary perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use The present invention provides a novel class of compounds useful for modulating beta-secretase (bace) enzyme activity. the compounds have a general formula i wherein a4, a5, a6, a8 variables, each of ra, rb, r1, r2, r3 and r7 of formula i, independently, are as defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for the treatment of disorders and / or conditions related to the formation and deposition of α-beta plaque resulting from the biological activity of bace. Such bace-mediated disorders include, for example, Alzheimer's disease, cognitive deficits, cognitive impairment, schizophrenia, and other central nervous system conditions. The invention further provides compounds of formulas II and III, and embodiments of sub-formulas thereof, intermediates and methods for preparing the compounds of the invention. |