| abstract |
Summary Bicyclic 2,3-benzodiazepines and substituted spirocyclic 2,3-benzodiazepines. inhibitory bet protein, in particular inhibitory brd4, substituted bicyclic and spirocyclic 2,3-benzodiazepines of the general formula (i), pharmaceutical compositions consisting of the compounds according to the invention, and their prophylactic and therapeutic use for hyperproliferative diseases, are described, especially tumoral diseases. In addition, the use of bet protein inhibitors in benign hyperplasia, atherosclerotic disease, sepsis, autoimmune disease, vascular disease, viral infection, neurodegenerative disease, inflammatory disease, atherosclerotic disease, and male fertility control is also described. 1/1 |