| abstract |
crispr-cas component systems, methods and compositions for manipulating sequences The invention provides systems, methods, and compositions for manipulating sequences and/or target sequence activities. vectors and vector systems are also provided, some of which encode one or more components of a crispr complex, as well as methods for drawing and using these vectors. methods of directing the formation of the crispr complex in eukaryotic cells and methods of selecting specific cells by introducing precise mutations using the crispr/cas system are also provided. |