http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-112015005343-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5053f82a7cd17c60822674b657cfb89e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2013-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1af1b24dd842cdf628e6b54769b1d9de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73f7ff612a503638f060c136ce07067b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e10e625e16184c37df7226caaa93ef3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2df3acb377516dfa865bd68f7e853c98 |
| publicationDate | 2017-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-112015005343-A2 |
| titleOfInvention | process for the preparation of bortezomib, compound, bortezomib or its anhydride, and process for the preparation of a compound |
| abstract | 1/2 summary â € œprocess for the preparation of bortezomib, compost, bortezomib or its anhydride, and process for preparing a compoundâ € ƒâ € ƒâ € ƒ3 ch 3 The present invention provides precocity. improved ch 3 3 hoon preparation of bortezomib, tert-butyl [1 - ({(1s) -3-methyl-1 - [(3as, 4s, 6s, 7as) - ch nb 3 ho 3a , 5,5-trimethylexhydro-4,6-methane-1,3,2-benzodioxaborol-2-yl] butyl} amino) -1-oxo-3-phenylpropan-2-yl] carbamate of formula (iv) ( iv) and n - {(1s) -3-methyl-1 - [(3as, 4s, 6s, 7as) -3a, 5,5-trimethylexahydro-4,6-methane-1,3,2-benzodioxaborol-2 -yl] butyl} phenylalanine of the formula (v) hc 3 ch 3 o ch ch 3 3 ohn 2 nb ch 3 ho (v). compound (iv) is prepared by coupling (1r) -3-methyl-1 - [(3as, 4s, 6s, 7ar) -3a, 5,5-trimethylhexahydro-4,6-methane-1,3, 2-benzodioxaborol-2-yl] butan-1-amine of formula (ii) hc 3 ch ch 3 ch 3 3 ob ch 3 ohn 2 (ii) or its salt with n- (tert-butoxycarbonyl) -1-phenylalanine fan (iii) 2/2 ohon oh (iii) in a first solvent in the presence of a first coupling agent and a first base, wherein the coupling process does not comprise solvent exchange. Compound (v) is prepared by deprotecting compound (iv) using an alcoholic solution of an inorganic acid. |
| priorityDate | 2012-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.