| abstract |
partially cross-linked esterified cellulose ether, composition, solid dispersion, process for producing the solid dispersion, dosage form and capsule shell. a partially cross-linked esterified cellulose ether having (a) groups of the formula -c (o) -r-cooa or a combination of monovalent acyl groups and groups of the formula -c (o) -r-cooa, in which r is a group bivalent aromatic or aliphatic hydrocarbon and a is hydrogen or a cation, and (b) have a molecular weight distribution such that [wf (> 100k) -wf (> 100k) xl] / wf (> 100k) xl is at least 0 , 20, where wf (> 100k) is the total weight fraction of the esterified cellulose ether that exceeds 100,000 g / mol, and wf (> 100k) xl is the weight fraction that exceeds 100,000 g / mol of the esterified methylated cellulose ether , is useful as an enteric polymer for pharmaceutical dosage forms. |