| abstract |
composition, dosage form, and, methods to treat heart failure, kidney disease, hypertension, hyperkalaemia, hypernatremia, a state of fluid overload, a state of poor fluid distribution, edema, ascites, nephrotic syndrome, to treat weight gain excessive interdialytic, and to treat a disease or disorder the present disclosure generally relates to compositions comprising a cross-linked cation-binding polymer comprising monomers containing carboxylic acid groups and pka-reducing groups, including electron withdrawing substituents, such as atoms halide (for example, fluorine) and a base, where the polymer optionally contains less than about 20,000 ppm of non-hydrogen cations and where the base is present in an amount sufficient to provide about 0.2 equivalent to about 0.95 equivalent of base per equivalent of carboxylic acid groups in the polymer. the present disclosure also relates to methods of preparing said compositions and methods of using said compositions to treat various diseases or disorders. |