| abstract |
abstract "methods and compositions for treating atherosclerotic vascular diseases" The present invention provides methods and compositions for treating atherosclerotic vascular diseases by cyclohexenone compounds. in some embodiments, the compound in the methods inhibits pdf-stimulated proliferation or migration of smooth muscle cells. in some embodiments, atherosclerosis is associated with coronary artery disease, aneurysm, arteriosclerosis, myocardial infarction, embolism, stroke, thrombosis, angina, vascular plaque inflammation, vascular plaque rupture, kawasaki disease, calcification or inflammation. in some embodiments, the compound reduces low density lipoprotein (ldl) cholesterol in the subject. in some embodiments, the compound maintains a normal to low density lipoprotein (ldl) cholesterol level in the subject. |