| abstract |
LIPOPEPTIDIC COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITION AND THEIR USE.nProvided here, they are antibacterial compounds, in which the compounds, in some embodiments, have a broad spectrum of bioactivity. The compounds provided herein can, in other embodiments, overcome the resistance conferred by single amino acid mutations at defined positions of bacterial signal peptidases (SPases) and, in other embodiments, to provide a broad spectrum of antibiotic bioactivity . Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided. |