abstract |
l nucleic acid molecule, its uses, pharmaceutical composition, complex, method for evaluating an antagonist of a c5a-mediated activity, kit and method for detecting a l nucleic acid. the present invention relates to a nucleic acid molecule capable of binding human c5a, wherein the nucleic acid molecule comprises a central nucleotide span, wherein the central nucleotide span comprises a 5' nucleotide sequence augn1ggugkun2n3rggghugukgggn4gn5cgac -gca 3' [seq id no: 61], where n1 is u or du, n2 is g or dg, n3 is a or da, n4 is u or du, n5 is u or du, and g, a, u, c , h, k and r are ribonucleotides and du, dg and da are 2'-deoxyribonucleotides. |