| abstract |
Naphthylacetic Piperidinyl Acids The invention relates to the compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R1, R2, R3 and X are defined in the detailed description and in the claims. furthermore, the present invention relates to methods of manufacture and use of the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the crth2 receptor and may be useful in treating diseases and disorders associated with such a receptor, such as asthma. |