| abstract |
Patent Summary: "5- (Pyridin-2-yl-amino) -pyrazine-2-carbonitrile compounds and their therapeutic use". The present invention generally relates to the field of therapeutic compounds. more specifically the present invention relates to certain pyridyl amino pyrazine carbonitrile compounds which, inter alia, inhibits the checkpoint kinase 1 (chk1) kinase function. The present invention also relates to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit chk1 kinase function, and in the treatment of diseases and conditions that are mediated by chk1. are enhanced by inhibiting chk1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example (a) a topoisomerase i or ii inhibitor; (b) a DNA damage agent; (c) an antimetabolite or thymidylate synthase inhibitor (ts); (d) a microtubule targeted agent; and (e) ionization radiation. |