| abstract |
patent summary: "aminopyrimidine kinase inhibitors". The present invention relates to aminopyrimidine compounds, pharmaceutical compositions containing such compounds, and uses of the compounds and compositions as modulators of ck1, ck1? 1, ck1? 2, ck1? 3, ck2, pim1, pim2, pim3, the pathway. from tgfß, the wnt pathway, the jak / stat pathway, the akt pathway, and / or the mtor pathway. Also disclosed are the uses for treating or preventing a number of therapeutic indications due at least in part to the aberrant physiological activity of ck1, ck1? 1, ck1? 2, ck1? 3, ck2, pim1, pim2, pim3, the tgfß pathway, the wnt pathway, the jak / stat pathway, the akt pathway, and / or the mtor pathway. 21160244v1 1/1 21160244v1 |