http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-112014010327-B8
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e5274636b970903a2f455eed740091c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-16 |
| filingDate | 2011-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e7fba4be8d2d9fbdf197768360ea423 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e007bd455e1416bf1064fc29e769d4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42b979c85a4ed3ee77922a88ed282997 |
| publicationDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-112014010327-B8 |
| titleOfInvention | process for the preparation of compounds |
| abstract | process for the preparation of compounds. The invention discloses an improved process for the preparation of aromatic 3,5-disubstituted-2,4,6-triiodine amines of formula (ii), wherein R 1 and R 2 are as defined herein. The compounds of formula (ii) are the key intermediates for the synthesis of a series of nonionic contrast agents such as iopamidol, ioexole and iodixanol. The process comprises reacting chlorine free iodination reagents with aromatic 3,5-disubstituted-2,4,6-triiodo amines to obtain aromatic 3,5-disubstituted-2,4,6-triiodo amines of formula (ii), wherein: that the molar yield of the iodation reaction can reach 89%. |
| priorityDate | 2011-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.