| abstract |
abstract “pyrazoloquinoline derivatives” a compound, represented by formula (i), or a pharmacologically acceptable salt thereof, which has pde9 inhibitory action such that it is expected to be able to raise the level of cgmp in the brain. Since the inhibitory action on pde9 and an increase in the level of cgmp contribute to the improvement of learning and memory behaviors, the aforementioned compound (i), or a pharmacologically acceptable salt thereof, will be available as a drug for cognitive dysfunctions. in Alzheimer's disease. wherein R1 represents a hydrogen atom; R2 represents an aromatic ring group, etc.; R3 represents a hydrogen atom, etc.; R4 represents a is a hydrogen atom; R5 represents an oxepanyl group, etc.; R6 represents a hydrogen atom. |