abstract |
Sustained-release lipid pre-concentrate and pharmaceutical composition. disclosed is a sustained-release lipid preconcentrate comprising: a) an unsaturated fatty acid ester of sorbitan that has a polar head with at least two or more -oh (hydroxyl) groups, b) a phospholipid, and c) a scavenging agent. liquid crystal hardening, free of an ionizable group, which has a hydrophobic portion of 15 to 40 carbon atoms with a triacyl group or a carbon ring structure. the lipid preconcentrate exists as a liquid phase in the absence of aqueous fluid and forms into a liquid crystal in the presence of an aqueous fluid. further, a pharmaceutical composition which further comprises a pharmacologically active ingredient in addition to the pre-concentrate is provided. |