| abstract |
abstract provided herein are methods, compounds, and compositions for reducing expression of apociii mrna and protein in an animal. also provided herein are methods, compounds, and compositions for increasing hdl levels and / or improving the ratio of tg to hdl and reducing plasma lipids and plasma glucose in an animal. such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof. translation of the abstract patent specification: "expression modulation of apoliprotein ciii (apociii)". Methods, compounds and compositions for reducing apocIIi mRNA and protein expression in an animal are provided herein. Also provided herein are methods, compounds and compositions for raising hdl levels and / or improving the ratio of tg to hdl and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds and compositions are useful for treating, preventing, retarding or ameliorating any or more of cardiovascular disease or metabolic disorder or a symptom thereof. |