| abstract |
antibodies directed against icos and their use. the present invention provides antibodies directed against icos or a derivative thereof which neutralize the coupling of icos in treg by inhibiting the fixation between icos and icos-1 and cancel the proliferation of treg induced by plasmacytoid dendritic cells. the present invention further provides antibodies directed against icos or a derivative thereof which induce the production of il-10 and ifn (gamma), induce the proliferation of cd4 + t cells, reduce the proliferation of tconv and increase the immunosuppressive function of treg. |