| abstract |
Patent Summary: "Benzodioxane Inhibitors of Leukotriene Production". The present invention relates to the compounds of formula (I): wherein R 1 to R 3, a, x and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene a4 hydrolase (lta4h) and in the treatment of lta4h-related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds. |