abstract |
Process for the preparation of 4-amino-3-chloro-5-fluoro-6- (substituted) picolinates The present invention relates to 4-amino-3-chloro-5-fluoro-6- (substituted) picolinates which are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange and hydrolysis, esterification and transition metal-assisted coupling. |