abstract |
INACTIVATED POLIOVACINE. The present invention provides an attenuated poliovirus having a 5 'non-coding region consisting of Sabin 3's 5' non-coding region, modified so that it does not have a base pair mismatch on stem (a) or (b) , domain V, where seven or eight of the base pairs of the stems (a) and (b) are UA or UA pairs, and a capsid protein from the Sabin 1, Mahoney, MEF or Saukett strain. |