| abstract |
USES OF POLYANIONS THAT INHIBIT THE CYTOToxic ACTIVITY OF HISTONES. The invention relates to a process of inhibiting cytotoxic activity of extracellular histones in an individual, comprising administering an effective amount of a polyanion to the individual. In particular, the invention relates to a process for the treatment of patients suffering from sepsis and employs polyanions to quickly form complexes with, and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the bloodstream. of sepsis patients. |