| abstract |
TARGET LEGUMAIN LIPID, TARGET LEGUMAIN NANOPARTICLES COMPOSITION AND USES THEREOF. The present invention provides an aqueous composition of tumor target liposome nanoparticles comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a preformed liposome composition or can be incorporated into liposomes during liposome formation. The liposome nanoparticles comprise a target legumain lipid in admixture with one or more other vesicle or micelle forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred composition of target tumor liposome nanoparticles comprises (a) a target legumain lipid component, (b) a zwitterionic lipid component, (c) an amino substituted lipid component, (d) a neutral lipid component, and (and ) a lipid component conjugated to polyethylene glycol. The target legumain lipid component comprises a covalent hydrophobic lipid moiety linked to a legumain binding moiety. |