| abstract |
filler composition and its use process for the preparation of the injection filler composition. the present invention relates to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in treating malignant cells with primary or secondary resistance, against a measles oncolytic virus without suicidal gene activity. moreover, the present invention relates to a measles vaccine-based recombinant measles virus schwarz strain that encodes a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase and a uracil phosphoribosyltransferase, especially uracil phosphoribosyltransferase of yeast, to a method and kit for the preparation of recombinant measles virus as claimed herein. |