| abstract |
pharmaceutical compositions of metabotropic glutamate receptor antagonists 5 (mglu5). The present invention relates to antagonist compositions of metabotropic glutamate receptor 5 (mglu5) or a pharmaceutically acceptable salt thereof. the compositions contain the therapeutic active compound with non-ionic polymer and ionic polymer, binders and fillers either in matrix pellets, matrix tablets or coated pellets. the compositions provide a ph-independent in vitro release profile with nmt of 70% in one hour, nmt of 85% in 4 hours, and nlt of 80% in 8 hours. the compositions are useful for treating CNS disorders such as treatment resistant depression (trd) and fragile X syndrome. |