| abstract |
multifunctional antibody conjugates. The present invention relates to multifunctional antibody conjugates, comprising an antibody or antigen binding portion thereof, comprising at least one fragment of a light chain constant kappa region (clk) comprising k <sym>, according to the numbering of the present invention. of kabat; a linker comprising the formula xyz, wherein z is a group that is covalently attached to the antibody via the k <sym> side chain, y is a linear or branched biologically compatible connecting chain, eg is a group covalently attached to at least an effector portion. The invention further provides specific mac compounds and compositions of the invention. |