http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-112013000629-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ee873b7eccd6071866fad852858f46d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5386 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-34 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5386 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 |
| filingDate | 2011-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b90c708f7ca9dee0c649d57d8372f7db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd3e8902bb7c0a92357e3bc742853309 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10660c67e54c8b554b1fda6c3f837282 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b8e3dff2ae1bf0b1ec6b087f239ea89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41dacee105f51869c8bd0f98b9c3b29b |
| publicationDate | 2016-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-112013000629-A2 |
| titleOfInvention | spiro-cyclic amine derivatives as s1p modulators |
| abstract | spiro-cyclic amine derivatives as s1p modulators. The present invention relates to the spiro-cyclic amine derivatives of formula (I) wherein R1 is selected from cyano, (2-4c) alkenyl, (2-4c) alkynyl, (1-4c) alkyl each optionally substituted with cn or one or more fluorine atoms, (3-6c) cycloalkyl, (4-6c) cycloalkenyl or a (8-10c) bicyclic group each optionally substituted with halogen or (1-4c) alkyl, phenyl, biphenyl naphthyl, each optionally substituted with one or more substituents independently selected from halogen, cyano, (1-6c) alkyl optionally substituted with one or more fluorine atoms, (1-6c) alkoxy optionally substituted with one or more fluorine atoms optionally phenyl substituted amino, di (1-4c) alkylamino and (3-6c) cycloalkyl which may be substituted with (1-4c) alkyl or halogen, phenyl substituted with phenoxy, benzyl, benzyloxy, phenylethyl or monocyclic heterocide each one optionally substituted with (1-4c) alkyl optionally substituted with one or more fluorine atoms, optionally independently substituted halogenated monocyclic heterocycle, (1-6c) alkyl optionally substituted with one or more fluorine atoms, (3-6c) cycloalkyl, or optionally substituted with (1-6c) phenyl 4c) alkyl or halogen, and bicyclic heterocycle optionally substituted with halogen or (1-4c) alkyl optionally substituted with one or more fluorine atoms; -y- (C n -alkylene) -x- is a bonding group wherein y is bonded to r1 and selected from a bond, -o-, co-, -s-, -so-, -so- 2 ~, -nh-, -ch = ch-, -c (cf-3 ~) = ch-, -c <sym> c-, -ch-2--o-, -o-co-, -co -o-, -co-nh-, -nh-co-, and trans-cyclopropylene; n is an integer from 0 to 10; ex is bonded to the phenylene / pyridyl component and selected from a bond, -o-, -s-, -so-, -so-2-, -nh-, -co-, -ch = ch-, and trans cyclopropylene; R2 is h or independently selected from one or more substituents selected from halogen, (1-4c) alkoxy and (1-4c) alkyl optionally substituted with one or more fluorine atoms; and R3 is (1-4c) alkylene-R4 wherein the alkylene group may be substituted with one or more halogen atoms or with (CH2-2) -2 to form a cyclopropyl component, or R3 is (3 -6c) cycloalkylene-r4, -ch-2- (3-6c) cycloalkylen-r4, (3-6c) cycloalkylene-ch-2- r4 or -co-ch-2-r4, wherein r4 is - oh, -po ~ 3 ~ h ~ 2 ~ -r4, where r4 is -oh, -po ~ 3 ~ h ~ 2 ~, opo ~ 3 ~ h ~ 2 ~, -cooh, -coo (1-4c) alkyl or tetrazol-5-yl; q is a bond or -o-; R5 is h or independently selected from one or more halogens; z is ch, cr2 or n; and a represents a morpholine ring structure or a 5.6 and 7 membered cyclic amine; or a pharmaceutically acceptable salt, solvate or hydrate thereof or one or more of its n-oxides. The compounds of the invention have s1p receptor affinity and may be used in the treatment, alleviation or prevention of diseases or conditions in which the s1p receptor (s) are involved. |
| priorityDate | 2010-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.