http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-112013000627-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ee873b7eccd6071866fad852858f46d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-429 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2011-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4891a0919b8bb822f351bcaab476ed76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f93e14759603a8df506fffd9d0dc58f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1165658054ec6aa434b47cf03640fbe3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_394b5d8a187ad736afa3e825d1f8f4dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6258a33b919a672e0b5180356b6fec8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fb44463c4c6aabe2d2eb06d1797cc0e |
| publicationDate | 2020-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-112013000627-B1 |
| titleOfInvention | fused heterocyclic derivatives as s1p modulators |
| abstract | fused heterocyclic derivatives as s1p modulators. the present invention relates to a heterocyclic derivative of formula (i) wherein r1 is selected from cyano, alkenyl (2-4c), alkynyl (2-4c), alkyl (1-4c), each substituted with cn or a or more fluorine atoms, cycloalkyl (3-6c), cycloalkenyl (4-6c) or a bicyclic group (8-10c), each substituted with halogen or alkyl (1-4c) optionally substituted with one or more fluorine atoms , phenyl, biphenyl, naphthyl, each substituted with one or more substituents independently selected from halogen, cyano, alkyl (1-4c) optionally substituted with one or more fluorine, alkoxy (1-4c) atoms optionally substituted with one or more fluorine, amino, dimethylamino, and cycloalkyl (3-6c) atoms optionally substituted with phenbyl which can be substituted with alkyl (1-4c) or halogen, and phenyl substituted with phenoxy, benzyl, benzyloxy, phenylethyl or monocyclic heterocycle, each substituted with alkyl (1-4c), z is a linking group - w- (alkylene-cn) -t- where w is li connected to r1 and selected from a link, -o-, -co-, -s-, -so-, -so ~ 2 ~ -, -nh-, -ch = ch-, -c (cf ~ 3 ~) = ch-, -c <sym> c-, -ch ~ 2 ~ -o-, -o-co-, -co-o-, -co-nh-, -nh-co- and trans-cyclopropylene; n is an integer from 0 to 10; et is attached to the phenylene / pyridyl portion and selected from a bond, -o-, -s-, -so-, -so ~ 2 ~ -, -nh-, -co-, -c <sym> c-, -c <sym> c-, and trans-cyclopropylene; r2 is h or one or more substituents independently selected from cyano, halogen, alkyl (1-4c) optionally substituted with one or more halogen atoms, or alkoxy (1-4c) optionally substituted with one or more halogen atoms; the structure of ring a may contain a nitrogen atom; x is selected from c or n; if x is c, r3 is selected from h and alkyl (1-4c), otherwise r3 is not present; y is selected from nh, o and s; structure q is a 5,6 or 7-membered cyclic amine; and r4 is alkylene (1-4c) -r5 in which one or more carbon atoms in the alkylene group can be independently replaced with one or more halogen atoms or (ch ~ 2 ~) ~ 2 ~ to form a cyclopropyl moiety. , or r4 is cycloalkylene (3-6c) -r5, -ch ~ 2 ~ -cycloalkylene (3-6c) -r5, cycloalkylene (3-6c) -ch ~ 2 ~ -r5 or -co-ch ~ 2 ~ - r5, where r5 is -oh, -po ~ 3 ~ h ~ 2 ~, -op ~ 3 ~ h ~ 2 ~, -cooh, -cooalkyl (1-4c) or tetrazol-5-yl; or a pharmaceutically acceptable salt, a solvate or hydrate thereof or one or more n-oxides thereof. the compounds of the invention have an affinity for sp1 receptors and can be used in the treatment, evaluation or prevention of diseases and conditions in which (any) s1p receptor (s) is (are) involved or in which the modulation of the system endogenous s1p signaling via any receiver is involved. |
| priorityDate | 2010-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 267.