| abstract |
5,6-dihydro-2h- [1,4] oxazin-3-ylamine derivatives useful as beta-secretase (bace) inhibitors. The present invention relates to novel 5,6-dihydro-2h- [1,4] oxazin-3-ylamine derivatives as beta-secretase inhibitors, also known as beta-site amyloid cleavage enzyme, bace, bace1, asp2, or memapsin 2. the invention is also directed to pharmaceutical compositions comprising such compounds, processes for preparing such compounds and compositions, and the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as alzheimer's (ad), mild cognitive impairment, senility, dementia, dementia with lewy bodies, down syndrome, dementia associated with stroke, dementia associated with parkinson's disease and dementia associated with beta-amyloid. |