| abstract |
parathyroid hormone analog polypeptide, its use and production method, as well as nucleic acid, expression vector, cell and pharmaceutical composition. the present invention is based on the development of two pth analog ligands, sp-pth-aak and aib-sp-pth-aak, which have long-acting activity at the pth receptor, as demonstrated in vitro and in vivo. these polypeptides are thus particularly useful in the treatment of diseases such as hypoparathyroidism, in which long-acting activity is desired. |