| abstract |
method to diagnose melanocytic proliferations. the invention provides a method for diagnosing a melanocytic proliferation in an individual comprising staining a sample of lesional melanocytes with an antibody against soluble adenylyl cyclase (sac) and interpreting the sac staining pattern, which is associated with the diagnosis of a melanocytic proliferation. the sac staining pattern, which is complex, is discriminatory and distinct according to the nature of melanocytic proliferation. the sac staining pattern comprises one or more of the points similar to golgi staining, wide granular golgi staining, diffuse cytoplasmic staining, nucleolar staining, incomplete nuclear granular staining, and pan-nuclear staining. the method of the invention is particularly useful for confirming the diagnosis or disaffirming achieved through conventional histological examination of a sample. in addition, the invention provides a kit for use in interpreting melanocytic proliferations. |