| abstract |
compound, pharmaceutical composition and use of a compound the present invention relates to pyrazol-4-yl-heterocyclyl-carboxamide compounds of formula i, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, where x is a thiazolyl, picolinyl, pyridinyl, pyrimidinyl, or fluoropyridinyl ring, are useful for inhibiting pim kinase, and for treating disorders such as cancer mediated by pim kinase. methods of using the compounds of formula i for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are described. |