| abstract |
method to improve the dissolution of the anticoagulant agent. it is desirable to provide a pharmaceutical composition containing a compound represented by the formula (i), or a pharmaceutically acceptable salt thereof, or a solvate thereof, which has an inhibitory effect on the activated blood clotting factor x, and which is useful as an agent to prevent and / or treat thrombosis, wherein the pharmaceutical composition has favorable dissolving properties. the present invention provides a method for producing a pharmaceutical composition containing a compound represented by formula (i), comprising the step of mixing a compound represented by formula (i) or a pharmaceutically acceptable salt thereof, or a solvate thereof, one or more excipients selected from the group consisting of a sugar alcohol and an additive that swells with water, a disintegrant and a binder under conditions to maintain the maximum water content of the angles during granulation at 10% or less. |