| abstract |
BENZISOXAZOLES AND AZABENZISOXAZOLES AS MGLUR4 ALLOSTERIC ENHANCEMENTS, COMPOSITIONS AND METHODS OF TREATMENT OF NEUROLOGICAL DYSFUNCTION. Benzisoxazole and azabenzisoxazole compounds that are useful as allosteric enhancers/positive allosteric modulators of metabotropic glutamate receptor subtype 4 (mG1uR4); synthesis methods for producing the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in the treatment of neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. |