| abstract |
process for the preparation of lacosamide. A novel process for the synthesis of lacosamide using d, l-serine as a starting material is described, in which the hydroxy methylation reaction is performed using a low cost base such as, and is not a low cost alkylating agent. Toxic and non-carcinogenic, such as methyl ptoluenesulfonate, the r enantiometer is isolated from the racemic mixture of lacosamide after selective hydrolysis of acetamide, salification of the racemic mixture with a chiral acid (hx *) in an organic solvent, decomposition. of the diastereoisomeric mixture, preferably by precipitation of the enantiometer r, and subsequent acetylation of the optically pure intermediate. |