| abstract |
muteins of human lipocalin 2 (lcn2, hngal), their use and methods of production and generation, nucleic acid, host cell, composition and kit. the present invention relates to a new library for the generation of muteins and the new derived muteins and human lipocalin 2 (lcn2, hngal) and related proteins that bind to a given target with detectable affinity. the invention also concerns the corresponding nucleic acid molecules encoding such a mutein and a method for its generation. the invention further relates to a method for producing such a mutein. for example, such muteins may serve to bind and deplete pathological forms of natural biomolecules such as amyloid beta peptide in alzheimer's disease or may target the extra domain of fibronectin b that is associated with tumor neovasculature. |