| abstract |
acylamino substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals. The present invention relates to compounds of formula I, wherein a, y, z, r 20, r 22 and r 50 have the meanings indicated in the claims which are valuable pharmaceutical active compounds. specifically, they are inhibitors of the endothelial differentiation gene 2 receptor (edg-2, edg2), which is activated by lysophosphatidic acid (lpa) and are similarly termed as lpa ~ 1 ~ receptor, and are useful for treatment. of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention further relates to processes for the preparation of the compounds of formula I, their use and pharmaceutical compositions comprising them. |