| abstract |
heterocyclic derivatives as glutaminyl cyclase inhibitors. the invention relates to new pyrrolidine derivatives of formula (i) in which r1, r2, r3 are as defined herein, as glutaminyl cyclase inhibitors (qc, ec 2,3,2,5). qc catalyzes the intramolecular cyclization of n-terminal glutamine residues in pyroglutamic acid (5-oxo-prolyl, pglu *) under ammonia release and the intramolecular cyclization of n-terminal glutamate residues in pyroglutamic acid under water release. |