http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-112012006389-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_261820c1464b2ef0a6c572434b633e12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2010-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_190e66fb8ec06f743143a5e3d134263f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f0727e22a41ab4feafd2d6eea20af0d |
| publicationDate | 2016-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-112012006389-A2 |
| titleOfInvention | peptide depleting agent, methods for producing a peptide clearance agent, and enzyme-directed enzyme prodrug therapy, and use of a peptide |
| abstract | peptide clearance agent, methods for producing a peptide clearance agent, and antibody-directed enzyme prodrug therapy, and use of a peptide. A peptide clearance agent is provided for the clearance of an enzyme conjugate and a binding molecule that specifically binds to the target site from a non-target site in a patient. The peptide clearance agent binds to the active site of the enzyme. The peptide also binds to the asialoglycoprotein receptor expressed by liver cells to facilitate clearance through the liver. The peptide may be glycosylated to facilitate clearance across the liver by binding to liver cells expressing an asialoglycoprotein receptor. typically, the peptide prevents or inhibits enzyme activity in enzyme binding and is not substantially modified by enzyme activity. the peptide may be based on amino-naphthoic acid (ana) -glutamate (glu) and may comprise the amino acid sequence serine (ser) -alanine (ala) -amino-naphthoic acid (ana) -glutamate (glu). In such cases, the enzyme of interest is typically cpg2. |
| priorityDate | 2009-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.